Gardner Syndrome Dental Features — MFDS Part 1 MCQ

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ModerateHuman DiseaseGardner Syndrome Dental FeaturesMFDS Part 1

Which combination of oral and maxillofacial findings is classically associated with Gardner syndrome, an APC-associated variant of familial adenomatous polyposis?

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Correct answer: C — Multiple jaw osteomas, supernumerary teeth and odontomas

Gardner syndrome is associated with multiple osteomas, particularly affecting the mandible and skull, together with dental anomalies such as supernumerary or unerupted teeth and odontomas. These findings may become apparent on dental radiographs before intestinal polyposis is clinically recognised and should prompt appropriate medical and genetic referral. Amelogenesis imperfecta and dentinogenesis imperfecta are separate inherited disorders of enamel and dentine formation, respectively. Complete anodontia is associated with severe developmental or ectodermal disorders rather than Gardner syndrome. Bilateral parotid tumours are not a characteristic feature of APC-associated polyposis.

Reference: NHS England, National Genomic Test Directory: Rare and Inherited Disease Eligibility Criteria, R414 APC Associated Polyposis, July 2025. https://www.england.nhs.uk/wp-content/uploads/2018/08/rare-and-inherited-disease-eligibility-criteria-V8.1.pdf