PGCG vs CGCG — MFDS Part 1 MCQ
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Correct answer: E — Soft-tissue origin in the gingiva or alveolar mucosa, sometimes with superficial erosion of adjacent bone
A peripheral giant cell granuloma originates in the gingival or alveolar mucosal soft tissues. It may cause superficial ‘cupping’ erosion of the adjacent alveolar bone, but this does not make it a primary intraosseous lesion. In contrast, a central giant cell granuloma originates within jawbone and usually presents radiographically as a unilocular or multilocular radiolucency. The two lesions can be very similar histologically, and both contain osteoclast-like multinucleated giant cells, so option C is incorrect. Younger age, anterior jaw involvement, aggressive osteolysis, cortical perforation and greater recurrence are more characteristic of central giant cell granuloma, making D and E incorrect.
Reference: Katsikeris N, Chrysomali E, Angelopoulos AP. Diagnostic and therapeutic approaches in oral cavity granulomas based on new data concerning their origin and pathogenesis. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2018. https://pubmed.ncbi.nlm.nih.gov/30534805/