Mantle Dentine — MFDS Part 1 MCQ
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Correct answer: C — Mantle dentine mineralisation is initiated in association with matrix vesicles, whereas circumpulpal intertubular dentine forms through mineralisation of a collagen–proteoglycan matrix
Explanation lettering: E = shown as A · C = shown as B · A = shown as C · B = shown as E
A is correct. Mantle dentine is the first dentine formed, and its initial mineral nucleation is associated with matrix vesicles. Subsequent circumpulpal intertubular dentine mineralises within a collagen- and proteoglycan-rich matrix without the same matrix-vesicle dependence. Option B reverses these mechanisms. Both tissues are odontoblast-derived and collagen-containing, excluding C and D; type I, not predominantly type III, is the principal dentinal collagen. Matrix-vesicle-associated mantle dentine formation is not restricted to the root, excluding E. Coronal mantle dentine also contains relatively coarse collagen fibrils oriented mainly perpendicular to the future dentino-enamel junction and is somewhat less mineralised than circumpulpal dentine.
Reference: Goldberg M, Kulkarni AB, Young M, Boskey A. Dentin: structure, composition and mineralization. Frontiers in Bioscience (Elite Edition). 2011;3:711–735. https://pubmed.ncbi.nlm.nih.gov/3460990/