Haemochromatosis Oral Features — MFDS Part 1 MCQ

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ModerateHuman DiseaseHaemochromatosis Oral FeaturesMFDS Part 1

Which oral or facial finding is most characteristically associated with established iron overload in hereditary haemochromatosis?

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Correct answer: B — Diffuse bronze-grey pigmentation of the facial skin

Option B is correct. Progressive iron accumulation in clinically expressed hereditary haemochromatosis can produce increased skin pigmentation, classically a bronze or grey-brown appearance that may be evident on the face. Removable white plaques suggest oral candidosis rather than a direct manifestation of iron overload. Generalised fibrotic gingival enlargement is more typically drug-related or associated with haematological disease. Macroglossia suggests conditions such as amyloidosis or acromegaly, while multiple supernumerary teeth point towards a developmental disorder such as cleidocranial dysplasia. Reports of intraoral pigmentation in haemochromatosis are inconsistent, so facial skin pigmentation is the better-supported finding.

Reference: NHS England Genomics Education Programme, GeNotes Knowledge Hub: Hereditary haemochromatosis, Clinical features, reviewed 2026. https://www.genomicseducation.hee.nhs.uk/genotes/knowledge-hub/hereditary-haemochromatosis/