Marfan Syndrome Dental — MFDS Part 1 MCQ

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ModerateHuman DiseaseMarfan Syndrome DentalMFDS Part 1

Which combination of oral and craniofacial findings is most characteristically associated with Marfan syndrome?

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Correct answer: D — High, narrow palate, dental crowding and mandibular retrognathia

Marfan syndrome is associated with a high, narrow palatal vault, dental crowding and a relatively small or retrognathic mandible; temporomandibular dysfunction or subluxation may also occur. Cardiovascular history is important because aortic root and valvular disease are major complications. However, Marfan syndrome or aortic dilatation alone does not automatically require infective endocarditis prophylaxis; current SDCEP advice bases this on specified high-risk cardiac conditions and the planned procedure. Multiple supernumerary teeth with retained primary teeth suggests cleidocranial dysplasia. Generalised enamel defects suggest amelogenesis imperfecta. Parotid enlargement with xerostomia suggests Sjögren syndrome, while generalised gingival enlargement is associated with medication effects or hereditary gingival fibromatosis.

Reference: NHS Genomics Education Programme, Marfan syndrome — Knowledge Hub, 2026. https://www.genomicseducation.hee.nhs.uk/genotes/knowledge-hub/marfan-syndrome/