Oxidised Cellulose Mechanism — MFDS Part 1 MCQ
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Correct answer: E — Providing a local matrix that concentrates blood components and promotes intrinsic-pathway-dependent clotting
Explanation lettering: D = shown as A · E = shown as D · A = shown as E
A is correct. Oxidised cellulose acts locally: its fibrous matrix absorbs blood and concentrates erythrocytes, platelets and coagulation proteins, supporting formation of a clot. Experimental evidence also demonstrates intrinsic-pathway-dependent platelet activation, including involvement of factors VIII, IX and XII. It is not principally an antifibrinolytic, so B describes the action of agents such as tranexamic acid. It does not supply fibrinogen or thrombin, as a fibrin sealant would, making C incorrect. It has no systemic vitamin K-like action and therefore does not increase hepatic clotting-factor synthesis (D). Its effect is immediate and local rather than arising from increased platelet production, excluding E.
Reference: Krízová P et al. The influence of intrinsic coagulation pathway on blood platelets activation by oxidized cellulose. Journal of Biomedical Materials Research Part A. 2007;82(2):274-280. https://pubmed.ncbi.nlm.nih.gov/17274026/