skip to main content

Osteocyte Function — MFDS Part 1 MCQ

Instant feedback + full explanation. One question, done properly.

ModeratePhysiologyOsteocyte FunctionMFDS Part 1

A histological section of mature alveolar bone shows stellate cells embedded within lacunae and interconnected through canaliculi. What is the most characteristic primary function of these cells?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Detecting mechanical strain and coordinating osteoblast and osteoclast activity

The cells described are osteocytes: terminally differentiated osteoblast-lineage cells embedded in mineralised bone. Their lacunocanalicular network allows them to detect mechanical loading and convert it into biochemical signals that regulate bone formation and resorption through effects on osteoblasts and osteoclasts. Therefore, C is correct. Osteoblasts deposit osteoid and promote mineralisation, making B incorrect. Osteoclasts acidify and enzymatically resorb mineralised bone, so C describes osteoclast function. Enamel matrix is secreted by ameloblasts during tooth development, not osteocytes, excluding D. Cementum is principally formed by cementoblasts, excluding E. Osteocytes can also participate in local perilacunar matrix modification, but their defining physiological role is mechanosensation and coordination of remodelling.

Reference: Seddiqi H, Klein-Nulend J, Jin J. Bone tissue regeneration: role of osteocyte mechanosensing and mechanotransduction. Stem Cells Translational Medicine. 2026. https://pubmed.ncbi.nlm.nih.gov/41983616/