Midazolam vs Diazepam IV Sedation — MFDS Part 1 MCQ

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ModeratePharmacologyMidazolam vs Diazepam IV SedationMFDS Part 1

Diazepam was previously used for IV sedation in dentistry. Why has midazolam largely replaced it?

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Correct answer: D — Midazolam is water-soluble (less pain on injection), has shorter duration, and produces better amnesia

Diazepam is formulated in propylene glycol (causing pain and thrombophlebitis on injection). Midazolam is water-soluble (pH-dependent ring opening), causing less injection site pain. Its shorter duration, more reliable amnesia, and similar safety profile make it preferred.

Reference: Rang 2019 Pharmacology