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Denture Stomatitis Treatment — MFDS Part 1 MCQ

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ModeratePharmacologyDenture Stomatitis TreatmentMFDS Part 1

An immunocompetent adult has mild, localised Candida-associated denture stomatitis affecting the palatal mucosa beneath a complete upper denture. The patient has no contraindications or clinically significant interacting medicines. Which topical regimen is most appropriate?

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Correct answer: D — Miconazole oral gel applied four times daily after meals and retained in contact with the affected mucosa

Miconazole oral gel is an appropriate topical treatment for mild, localised Candida-associated denture stomatitis. In adults, it is applied four times daily after meals and retained in the mouth to maximise contact with the affected mucosa. The denture should also be removed at night and brushed with the gel; denture hygiene and a daily denture-free period are important to reduce recolonisation. Nystatin suspension can be an alternative when miconazole is unsuitable, but it must be retained in contact with the lesions rather than swallowed immediately. Fluconazole is supplied for systemic administration, not as capsule contents applied topically. Amphotericin treatment does not replace removal and cleaning of the denture. Terbinafine cream is a cutaneous preparation and is inappropriate for oral candidosis.

Reference: Daktarin Oral Gel, Summary of Product Characteristics, sections 4.1–4.2, current eMC version updated 11 May 2026: https://www.medicines.org.uk/emc/product/14746/smpc