Adrenaline Contraindications — MFDS Part 1 MCQ

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ModeratePharmacologyAdrenaline ContraindicationsMFDS Part 1

For routine dental use of a licensed lidocaine–adrenaline local anaesthetic, assuming there is no hypersensitivity to its active ingredients or excipients, which statement is correct?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: C — None of the listed medical factors is an absolute contraindication.

Explanation lettering: E = shown as A · C = shown as B · A = shown as C · B = shown as D · D = shown as E

A is correct. None of the medical factors listed is, by itself, an absolute contraindication to a licensed lidocaine–adrenaline preparation. The SmPC lists hypersensitivity to the active substances, amide local anaesthetics or excipients as contraindications. Hypertension, cardiac disease and advanced diabetes require caution, individual risk assessment, careful injection technique and use of the lowest effective dose; they are not automatically absolute prohibitions. Stable angina therefore requires greater care but differs from unstable cardiovascular disease, in which elective dental treatment may need to be deferred. Pregnancy is also not an absolute contraindication: clinically necessary dental treatment may proceed after benefit–risk assessment. The original explanation incorrectly described two cartridges as the maximum dose for a healthy adult; cartridge limits depend on the formulation, patient and clinical circumstances.

Reference: Aguettant Ltd. Lidocaine 20 mg/ml (2% w/v) with Adrenaline (Epinephrine) 1:200 000 solution for injection, Summary of Product Characteristics, sections 4.3, 4.4 and 4.6, updated 2026. https://www.medicines.org.uk/emc/product/101881/smpc