Incisional vs Excisional Biopsy — MFDS Part 1 MCQ
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Correct answer: C — A large, diffuse lesion for which histological diagnosis is required before definitive treatment
Explanation lettering: D = shown as A · C = shown as B · A = shown as C · B = shown as D
A is correct. An incisional biopsy removes a representative portion of a lesion to establish the histological diagnosis. It is appropriate when the lesion is too large or diffuse for complete removal at the diagnostic procedure, or when diagnosis is needed before planning definitive treatment. An excisional biopsy removes the whole lesion and is generally preferred for a small, localised, clinically benign abnormality when this can be achieved without significant morbidity. Therefore, the small benign-appearing lesion in B and the clinically typical, readily removable lesions in C, D and E would ordinarily be managed by excisional biopsy, with the specimen submitted for histopathological examination.
Reference: Cambridge University Hospitals NHS Foundation Trust. Oral (mouth) biopsy, section 'What is a biopsy?'. Accessed 2026. https://www.cuh.nhs.uk/patient-information/oral-mouth-biopsy/