Bioactive Glass Mechanism — MFDS Part 1 MCQ
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Correct answer: D — Dissolution and ion exchange release calcium, phosphate and soluble silicate species, followed by precipitation and maturation of an apatite-like calcium-phosphate layer
Explanation lettering: E = shown as A · C = shown as B · D = shown as C · A = shown as D · B = shown as E
A is correct. In saliva, calcium sodium phosphosilicate bioactive glass undergoes dissolution and ion exchange, providing calcium and phosphate and generating reactive silicate species. Calcium-phosphate material then precipitates and matures into an apatite-like mineralised layer, which may also occlude exposed dentinal tubules. Option B describes the setting and fluoride-release behaviour of a glass-ionomer cement. Option C is the mechanism attributed to casein phosphopeptide–amorphous calcium phosphate. Option D describes resin infiltration or resin-mediated sealing rather than bioactive mineral deposition. Option E describes the proposed neural action of potassium-containing desensitising products; it may reduce sensitivity but does not remineralise dentine or form an apatite layer.
Reference: Dai LL, Mei ML, Chu CH, Lo ECM. Mechanisms of Bioactive Glass on Caries Management: A Review. Materials. 2019;12:4183. https://pubmed.ncbi.nlm.nih.gov/31842454/