Jaw Osteosarcoma — MFDS Part 1 MCQ
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Correct answer: D — Later age at presentation; less frequent and later distant metastasis; better overall survival
Explanation lettering: B = shown as A · D = shown as B · A = shown as D
Jaw osteosarcoma generally presents later in life than conventional appendicular osteosarcoma. It also shows less frequent and later haematogenous metastasis, although achieving local control with complete resection is particularly important. Comparative systematic-review evidence indicates significantly better survival for craniofacial osteosarcoma, especially tumours arising in the jaws. Therefore, A is the best answer. Option B reverses the characteristic metastatic behaviour and survival pattern. Options C and D incorrectly place jaw osteosarcoma in a younger age group, while E overlooks established site-related differences. These are population-level tendencies rather than absolute features of every individual tumour.
Reference: Weber V, et al. Systematic review of craniofacial osteosarcoma regarding different clinical, therapeutic and prognostic parameters. Frontiers in Oncology. 2023;13:1006622. https://pubmed.ncbi.nlm.nih.gov/37035145/