Oral Papilloma — MFDS Part 1 MCQ
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Correct answer: A — Human papillomavirus
Human papillomavirus is the virus most commonly associated with oral squamous papilloma, particularly the low-risk genotypes HPV 6 and HPV 11. The lesion is usually a benign, painless, papillary or finger-like exophytic growth. Association is preferable to stating that every lesion is definitively caused by HPV because viral DNA is not demonstrable in all histologically diagnosed cases. Herpes simplex virus typically produces vesicles and ulcers rather than a persistent papilloma. Epstein–Barr virus is associated with oral hairy leukoplakia, while coxsackievirus causes conditions such as herpangina and hand, foot and mouth disease. Cytomegalovirus may cause oral ulceration, particularly in markedly immunocompromised patients.
Reference: Nguyen HP, McNiece KL, Duong AA, Khan F. Human papillomavirus infections of the oral mucosa and upper respiratory tract. Current Problems in Dermatology. 2014;45:132–153. https://pubmed.ncbi.nlm.nih.gov/24643183/