Oral Fibroma — MFDS Part 1 MCQ
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Correct answer: B — A reactive focal hyperplasia of fibrous connective tissue caused by chronic irritation
An irritation fibroma is a reactive focal hyperplasia of fibrous connective tissue, usually produced by repeated low-grade trauma such as cheek biting, a sharp tooth or an irritating prosthesis. Despite its conventional name, it is not a true benign fibroblastic neoplasm, so B is incorrect. It has no intrinsic malignant behaviour and does not require wide-margin oncological excision, excluding C. It is neither a virus-induced epithelial proliferation nor a developmental hamartoma, excluding D and E. Histologically, it typically consists of collagenised fibrous connective tissue covered by stratified squamous epithelium; inflammation may be present if the surface is ulcerated.
Reference: Yasuda M et al. Slow-Growing Large Irritation Fibroma of the Anterior Hard Palate: A Case Report Using Immunohistochemical Analysis. Journal of Medical Case Reports, 2016. https://pubmed.ncbi.nlm.nih.gov/27408447/