Gingival Crevicular Fluid — MFDS Part 1 MCQ
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Correct answer: C — Postcapillary venules of the gingival microvasculature
The correct answer is C. The fluid component of gingival crevicular fluid is derived principally from leakage through postcapillary venules in the gingival microvasculature. Plaque-induced inflammation increases vascular permeability and GCF flow; the fluid then reaches the gingival sulcus across the sulcular or junctional epithelial barrier. It contains plasma-derived proteins and locally generated inflammatory mediators and leucocytes. Minor salivary glands contribute to saliva, not GCF. Junctional epithelial cells regulate passage into the sulcus and contribute locally produced substances, but they are not the principal fluid source. The pulpal vascular plexus is anatomically separated from the gingival crevice. Gingival lymphatics drain interstitial fluid away from tissues rather than secreting it into the sulcus.
Reference: Subbarao KC et al. Gingival Crevicular Fluid: An Overview. Journal of Pharmacy & Bioallied Sciences. 2019;11(Suppl 2):S135-S139. https://pubmed.ncbi.nlm.nih.gov/31198325/