Recurrent Herpes Labialis — MFDS Part 1 MCQ
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Correct answer: D — Localised fluid-filled blisters on the lip, preceded by tingling, burning or itching
Recurrent herpes labialis presents as a localised cold sore on the lip or adjacent perioral skin. A prodrome of tingling, burning or itching commonly occurs before fluid-filled vesicles appear; these may subsequently rupture, ulcerate and crust. Diffuse painful oral ulceration with fever and malaise is more consistent with primary herpetic gingivostomatitis. Removable white plaques suggest pseudomembranous candidosis. Vesicles confined to the soft palate do not constitute herpes labialis, which principally affects the lip or perioral skin. A persistent painless indurated tongue ulcer requires urgent assessment for oral malignancy rather than being attributed to recurrent HSV infection.
Reference: NHS. Sore or dry lips, section: Common causes of sore or dry lips. Last reviewed 13 February 2025. https://www.nhs.uk/symptoms/sore-or-dry-lips/