Ecological Plaque Hypothesis — MFDS Part 1 MCQ
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Correct answer: A — Local environmental changes select disease-associated members of the resident microbiota, disrupting microbial homeostasis
Explanation lettering: C = shown as B · B = shown as C · E = shown as D · D = shown as E
A is correct. The ecological plaque hypothesis proposes that environmental pressures disturb microbial homeostasis and selectively enrich disease-associated organisms already present within the resident biofilm. Recurrent low pH favours acidogenic and aciduric organisms in caries, whereas inflammation-associated changes in nutrients, pH and redox conditions favour proteolytic obligate anaerobes in periodontal disease. B represents the specific plaque hypothesis and incorrectly requires a single decisive pathogen. C describes an exogenous-infection model, although relevant organisms may be detectable in health. D resembles the non-specific plaque hypothesis and ignores differences in bacterial physiology and virulence. E is incompatible with the characteristic ecological shift in the proportions and activities of the plaque community.
Reference: Marsh PD. Are dental diseases examples of ecological catastrophes? Microbiology. 2003;149:279–294. https://pubmed.ncbi.nlm.nih.gov/12624191/