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Ecological Plaque Hypothesis — MFDS Part 1 MCQ

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HardMicrobiologyEcological Plaque HypothesisMFDS Part 1

In one multispecies plaque model, repeated episodes of low pH enrich acidogenic, acid-tolerant bacteria without introduction of new species. In another model, inflammation increases gingival crevicular fluid and enriches proteolytic obligate anaerobes that were already detectable at low abundance in health. Which statement best unifies these findings according to the ecological plaque hypothesis?

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Correct answer: ALocal environmental changes select disease-associated members of the resident microbiota, disrupting microbial homeostasis

Explanation lettering: C = shown as B · B = shown as C · E = shown as D · D = shown as E

A is correct. The ecological plaque hypothesis proposes that environmental pressures disturb microbial homeostasis and selectively enrich disease-associated organisms already present within the resident biofilm. Recurrent low pH favours acidogenic and aciduric organisms in caries, whereas inflammation-associated changes in nutrients, pH and redox conditions favour proteolytic obligate anaerobes in periodontal disease. B represents the specific plaque hypothesis and incorrectly requires a single decisive pathogen. C describes an exogenous-infection model, although relevant organisms may be detectable in health. D resembles the non-specific plaque hypothesis and ignores differences in bacterial physiology and virulence. E is incompatible with the characteristic ecological shift in the proportions and activities of the plaque community.

Reference: Marsh PD. Are dental diseases examples of ecological catastrophes? Microbiology. 2003;149:279–294. https://pubmed.ncbi.nlm.nih.gov/12624191/