Opioid Reversal — MFDS Part 1 MCQ
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Correct answer: E — Naloxone
Naloxone is the correct answer. It is a competitive opioid-receptor antagonist used to reverse opioid-induced respiratory and central nervous system depression in suspected acute overdose. Its effect may wear off before that of a long-acting opioid, so the patient must be monitored and repeated doses or an infusion may be required. Flumazenil antagonises benzodiazepines, while N-acetylcysteine is used for paracetamol poisoning. Vitamin K reverses the anticoagulant effect of warfarin, and protamine sulphate neutralises heparin. Naloxone should accompany appropriate emergency assessment and airway and ventilatory support rather than replace basic resuscitation measures.
Reference: Electronic Medicines Compendium. Naloxone Hydrochloride 400 micrograms/ml Solution for Injection/Infusion, Summary of Product Characteristics, sections 4.1, 4.2 and 5.1; text revised 2023. https://www.medicines.org.uk/emc/product/6589/smpc