Woven vs Lamellar Bone — MFDS Part 1 MCQ

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ModeratePhysiologyWoven vs Lamellar BoneMFDS Part 1

Histological examination of newly deposited bone in a healing mandibular extraction socket shows woven rather than lamellar bone. Which combination of features best supports this identification?

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Correct answer: E — Randomly oriented collagen fibres and rapid deposition

Woven bone is characterised by rapidly deposited matrix containing randomly oriented collagen fibres, so E is correct. It is produced during embryonic osteogenesis and during adult repair, including fracture and extraction-socket healing, before being remodelled into more organised lamellar bone. Lamellar bone has aligned collagen arranged in lamellae and is deposited more slowly, making B a description of lamellar rather than woven bone. Woven bone is less mechanically competent than mature lamellar bone, excluding C. Concentric lamellae are a feature of organised lamellar bone, and woven bone does contain embedded osteocytes, excluding D. Woven bone is not confined to embryonic development because it also forms during repair and in some pathological states, excluding E.

Reference: Shapiro F, Wu J. Woven bone overview: structural classification based on its integral role in developmental, repair and pathological bone formation throughout vertebrate groups. European Cells and Materials. 2019;38:137–167. https://pubmed.ncbi.nlm.nih.gov/31571191/; Gorski JP. Is all bone the same? Critical Reviews in Oral Biology and Medicine. 1998;9(2):201–223. https://pubmed.ncbi.nlm.nih.gov/9603236/