Dentine Collagen — MFDS Part 1 MCQ

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ModeratePhysiologyDentine CollagenMFDS Part 1

Following removal of the mineral phase from mature dentine, which collagen type forms the predominant fibrillar scaffold of the remaining organic matrix?

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Correct answer: B — Type I collagen

Type I collagen is the predominant collagen of the dentine organic matrix and provides its principal fibrillar scaffold. Small quantities of other collagen types may occur, but they do not predominate. Type III collagen is associated mainly with reticular connective tissues and may be encountered in the dental pulp. Type II collagen is characteristic of cartilage. Type IV collagen forms sheet-like networks in basement membranes rather than the main fibrillar framework of dentine. Type VII collagen forms anchoring fibrils associated with epithelial basement membranes. Therefore, removal of dentine mineral exposes an organic matrix composed predominantly of type I collagen.

Reference: Linde A. Dentin matrix proteins: composition and possible functions in calcification. Anatomical Record. 1989;224(2):154–166. https://pubmed.ncbi.nlm.nih.gov/2672882/