Crohn Disease Oral Manifestations — MFDS Part 1 MCQ

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ModerateHuman DiseaseCrohn Disease Oral ManifestationsMFDS Part 1

A patient with established Crohn disease develops oral lesions. Which pattern is most characteristic of oral Crohn disease?

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Correct answer: D — Persistent lip swelling with mucosal cobblestoning

Persistent lip swelling with cobblestoned oral mucosa is characteristic of oral Crohn disease. Other specific findings include mucosal tags and deep linear ulceration; biopsy may demonstrate non-caseating granulomatous inflammation. These appearances overlap with orofacial granulomatosis, although orofacial granulomatosis can occur as a distinct disorder without intestinal Crohn disease. A velvety red plaque suggests erythroplakia, while a corrugated lateral-tongue plaque suggests oral hairy leukoplakia. Fragile bullae and desquamative gingivitis are compatible with pemphigus vulgaris, and migrating depapillated tongue patches describe geographic tongue.

Reference: Specific Oral Manifestations in Adults with Crohn's Disease, Journal of Clinical Medicine, 2024. https://pubmed.ncbi.nlm.nih.gov/38999519/