Hand Foot and Mouth Disease — MFDS Part 1 MCQ
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Correct answer: B — Coxsackievirus A16
Coxsackievirus A16 is an established common cause of hand, foot and mouth disease, which typically produces oral vesicles or ulcers together with a vesicular eruption on the hands and feet. The disease is not attributable to a single serotype: other enteroviruses, including enterovirus A71 and coxsackieviruses A6 and A10, may also cause it. Herpes simplex virus can cause primary herpetic gingivostomatitis or herpes labialis but does not produce the characteristic hand-foot-mouth distribution. Measles causes a febrile maculopapular exanthem with cough, coryza, conjunctivitis and Koplik spots; rubella typically causes a mild exanthem with lymphadenopathy; and mumps classically causes parotitis. Therefore, A is the only defensible option.
Reference: Klein M, et al. Changing Epidemiology of Hand, Foot, and Mouth Disease Causative Agents and Contributing Factors. American Journal of Tropical Medicine and Hygiene. 2024. https://pubmed.ncbi.nlm.nih.gov/39106854/