Central Giant Cell Granuloma — MFDS Part 1 MCQ

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ModerateOral PathologyCentral Giant Cell GranulomaMFDS Part 1

Central giant cell granuloma of the jaws is most commonly found in which anatomical location?

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Correct answer: B — Anterior mandible

The correct answer is B, the anterior mandible. Central giant cell granuloma occurs more often in the mandible than the maxilla, with the parasymphysis and other tooth-bearing anterior mandibular sites most frequently affected. A lesion may extend across the mandibular midline, although this is not present in every case. The posterior mandible can be involved but is less typical, while maxillary lesions are less common overall. The mandibular ramus is not a characteristic predominant site. The age and sex associations sometimes taught with this lesion are not needed to answer this anatomical-distribution question.

Reference: Boffano P et al. Diagnosis and management of central giant cell granulomas of the jaws: a European and multicenter study. Journal of Cranio-Maxillofacial Surgery. 2025;53(9):1455-1462. https://pubmed.ncbi.nlm.nih.gov/40544024/