Odontogenic Keratocyst — MFDS Part 1 MCQ
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Correct answer: E — Uniform 5–8-cell-thick parakeratinised stratified squamous epithelium with a corrugated surface and palisaded basal cells
Explanation lettering: C = shown as A · D = shown as B · E = shown as C · B = shown as D · A = shown as E
A is correct. A typical uninflamed odontogenic keratocyst has a thin, uniform lining of parakeratinised stratified squamous epithelium, usually about 5–8 cells thick. Its luminal surface is corrugated, while the hyperchromatic basal cells show palisading and often reversed nuclear polarity; rete ridges are generally absent. Option E describes an orthokeratinised odontogenic cyst, a separate entity with a prominent granular layer and bland, non-palisaded basal cells. Option B is more typical of an inflamed radicular cyst lining, and option D resembles the lining of a dentigerous cyst. Ciliated columnar epithelium may occur in cysts influenced by respiratory epithelium but is not the characteristic lining of an odontogenic keratocyst.
Reference: Soluk-Tekkeşin M, Wright JM. The World Health Organization Classification of Odontogenic Lesions: A Summary of the Changes of the 2022 (5th) Edition. Turkish Journal of Pathology. 2022. https://pubmed.ncbi.nlm.nih.gov/35578902/