HPV Vaccine 3 Doses HIV — SCE Infectious Diseases MCQ

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EasyTravel Medicine & VaccinationHPV Vaccine 3 Doses HIVSCE Infectious Diseases

A 35-year-old man with HIV on ART (CD4 450, VL <50) is offered the HPV vaccine (Gardasil 9). How many doses are recommended for immunocompromised patients?

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Correct answer: A — 3 doses (0, 2, and 6 months) — immunocompromised patients require 3 doses regardless of age (unlike immunocompetent individuals under 15 who receive 2 doses)

BHIVA and the Green Book recommend a 3-dose HPV vaccine schedule for immunocompromised patients (including PLWH), regardless of age. Immunocompetent children under 15 receive 2 doses, but those with HIV receive 3 doses due to potentially reduced immunogenicity. The schedule is 0, 2, and 6 months. Gardasil 9 (nonavalent) is the recommended formulation, providing coverage against HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58.

Reference: BHIVA 2024 – Vaccination; Green Book Ch 18a – HPV; JCVI 2023