A 40-year-old man with HIV on ART is diagnosed with latent syphilis of unknown duration. He has no neurological or ophthalmic symptoms. RPR is 1:16.

Question

A 40-year-old man with HIV on ART is diagnosed with latent syphilis of unknown duration. He has no neurological or ophthalmic symptoms. RPR is 1:16. His CD4 is 450 cells/µL. What is the treatment for late latent/unknown duration syphilis?

Accepted Answer

Benzathine Penicillin G 2.4 MU IM weekly for 3 consecutive weeks (3 doses total)

Answer

Benzathine Penicillin G 2.4 MU IM single dose as the preferred next step

Answer

Doxycycline 100 mg BD for 14 days as the preferred next management strategy

Answer

IV Benzylpenicillin for 14 days as the preferred next management strategy

Answer

Azithromycin 2 g single dose as the preferred next management strategy

Late Latent Syphilis 3 Doses — SCE Infectious Diseases MCQ

A 40-year-old man with HIV on ART is diagnosed with latent syphilis of unknown duration. He has no neurological or ophthalmic symptoms. RPR is 1:16. His CD4 is 450 cells/µL. What is the treatment for late latent/unknown duration syphilis?