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Pyrazinamide Gout Management — SCE Infectious Diseases MCQ

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HardTuberculosisPyrazinamide Gout ManagementSCE Infectious Diseases

A patient with HIV has Pneumocystis jirovecii pneumonia and a room-air PaO2 of 8.0 kPa. Which adjunct should be added to high-dose co-trimoxazole?

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Correct answer: E — Systemic corticosteroids

Adjunctive systemic corticosteroids reduce mortality in moderate-to-severe HIV-associated Pneumocystis pneumonia when hypoxaemia meets the treatment threshold, commonly PaO2 below 9.3 kPa on room air or a raised alveolar–arterial gradient. They should be started early, ideally within 72 hours of antimicrobial therapy, while monitoring for other opportunistic infections.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/infections