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UTI Delirium in Parkinson — SCE Infectious Diseases MCQ

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HardAntimicrobial StewardshipUTI Delirium in ParkinsonSCE Infectious Diseases

A patient taking levodopa–carbidopa becomes more tremulous and confused during a symptomatic urinary infection soon after trimethoprim is prescribed. Interaction checking shows no clinically important direct interaction. What is the best interpretation?

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Correct answer: C — Infection-related delirium and worsening of Parkinsonian motor function

The best answer is “Infection-related delirium and worsening of Parkinsonian motor function”. Acute infection commonly worsens Parkinsonian motor function and precipitates delirium; temporal association alone should not create a false drug-interaction diagnosis. Asymptomatic bacteriuria is not treated in non-pregnant adults unless a defined urological indication applies, because antibiotics add harm without clinical benefit.

Reference: NICE NG109: lower urinary tract infection antimicrobial prescribing: https://www.nice.org.uk/guidance/ng109/chapter/Recommendations