A farmer with a prosthetic aortic valve has culture-negative endocarditis, hepatitis and splenomegaly. Coxiella burnetii phase I IgG is markedly

Question

A farmer with a prosthetic aortic valve has culture-negative endocarditis, hepatitis and splenomegaly. Coxiella burnetii phase I IgG is markedly raised. Which treatment strategy is most appropriate?

Accepted Answer

Doxycycline plus hydroxychloroquine for prolonged specialist-guided therapy

Answer

Azithromycin monotherapy for six weeks without serological monitoring

Answer

Rifampicin plus isoniazid for six months with no valve assessment

Answer

Gentamicin plus flucloxacillin until blood cultures become negative

Answer

Ceftriaxone monotherapy for two weeks followed by surveillance

Brain Abscess Empirical CNS Antibiotics — SCE Infectious Diseases MCQ

A farmer with a prosthetic aortic valve has culture-negative endocarditis, hepatitis and splenomegaly. Coxiella burnetii phase I IgG is markedly raised. Which treatment strategy is most appropriate?