A clinically stable adult with non-CF bronchiectasis has a first sputum isolation of Pseudomonas aeruginosa and has never received eradication

Question

A clinically stable adult with non-CF bronchiectasis has a first sputum isolation of Pseudomonas aeruginosa and has never received eradication treatment. Which approach follows BTS guidance?

Accepted Answer

Discuss eradication treatment, commonly ciprofloxacin 500–750 mg twice daily for 2 weeks followed by an inhaled antipseudomonal antibiotic for 3 months

Answer

Treat only when the next symptomatic exacerbation occurs because eradication is confined to cystic fibrosis

Answer

Observe until three consecutive cultures are positive because one isolation never predicts chronic infection

Answer

Give intravenous dual antipseudomonal therapy to every stable first isolation

Answer

Use inhaled colistin indefinitely without an initial eradication course

Pseudomonas First Isolation Eradication — SCE Infectious Diseases MCQ

A clinically stable adult with non-CF bronchiectasis has a first sputum isolation of Pseudomonas aeruginosa and has never received eradication treatment. Which approach follows BTS guidance?