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Complement Screening Post-Meningococcal — SCE Infectious Diseases MCQ

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HardInfection Prevention & ControlComplement Screening Post-MeningococcalSCE Infectious Diseases

A young adult has a second episode of invasive meningococcal disease caused by a different serogroup. Which immune investigation is particularly important?

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Correct answer: E — Screen classical and alternative complement pathways and assess terminal complement components with review

The best answer is “Screen classical and alternative complement pathways and assess terminal complement components with review”. Terminal complement deficiency strongly predisposes to recurrent Neisseria infection and is not excluded by normal immunoglobulin concentrations. “Test only for HIV and stop if negative” does not match the decisive clinical feature or cited guidance. “Use skull-base imaging as the sole immune investigation” does not match the decisive clinical feature or cited guidance. “Measure total immunoglobulin alone” does not match the decisive clinical feature or cited guidance. “Perform no investigation because recurrence is expected” does not match the decisive clinical feature or cited guidance.

Reference: UKHSA meningococcal public-health guidance: https://www.gov.uk/government/publications/meningococcal-disease-guidance-on-public-health-management