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Vancomycin AUC Dosing — SCE Infectious Diseases MCQ

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HardAntimicrobial StewardshipVancomycin AUC DosingSCE Infectious Diseases

A patient receiving once-daily gentamicin for severe sepsis has worsening renal function. What is the correct therapeutic-drug-monitoring principle?

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Correct answer: D — Use timed levels and renal function to guide redosing

Extended-interval aminoglycoside dosing still requires a correctly timed concentration interpreted with the local nomogram or protocol, and renal function must be checked. In acute kidney injury the next dose may need to be withheld pending a level and specialist advice. Timing, indication, microbiology and cumulative ototoxic and nephrotoxic exposure all matter.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/infections