Sarcoidosis-Like IRIS — SCE Infectious Diseases MCQ

Correct answer: A — Sarcoidosis-like immune reconstitution inflammatory syndrome with documented specialist review with review after review with follow-up if needed

The best answer is “Sarcoidosis-like immune reconstitution inflammatory syndrome with documented specialist review with review after review with follow-up if needed”. Immune restoration can unmask non-infectious granulomatous inflammation; diagnosis still requires careful exclusion of infection and malignancy. “Kikuchi disease proved by non-caseating granulomas” is less appropriate because it conflicts with the clinical discriminator or cited guidance. “Lymphoma despite negative tissue assessment” is less appropriate because it conflicts with the clinical discriminator or cited guidance. “Tuberculosis despite adequate repeated negative microbiology and incompatible pathology” is less appropriate because it conflicts with the clinical discriminator or cited guidance. “Cat-scratch disease without exposure or suppurative histology” is less appropriate because it conflicts with the clinical discriminator or cited guidance.

Reference: BHIVA opportunistic-infection guidelines: https://bhiva.org/clinical-guideline/oi-guidelines/