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IVIG in Streptococcal TSS — SCE Infectious Diseases MCQ

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HardInfection Prevention & ControlIVIG in Streptococcal TSSSCE Infectious Diseases

A patient with streptococcal toxic shock syndrome has source control, appropriate beta-lactam and clindamycin therapy, but shock and organ failure remain severe. Which adjunct may be considered after specialist discussion?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Adjunctive intravenous immunoglobulin for refractory streptococcal toxic shock

The best answer is “Adjunctive intravenous immunoglobulin for refractory streptococcal toxic shock”. IVIG may neutralise circulating superantigens and can be considered in severe STSS, but evidence is limited and it never replaces source control, active antibiotics or intensive organ support. Invasive group A streptococcal disease requires prompt source control, active antimicrobials, toxin-suppressing therapy when indicated and health-protection involvement.

Reference: UKHSA invasive group A streptococcal disease guidance: https://www.gov.uk/government/collections/group-a-streptococcal-infections-guidance-and-data