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Schistosomal Bladder Cancer — SCE Infectious Diseases MCQ

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HardParasitologySchistosomal Bladder CancerSCE Infectious Diseases

A patient from an endemic region has painless terminal haematuria and terminal-spined Schistosoma eggs in urine. Which long-term malignancy is associated with this infection?

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Correct answer: ASquamous-cell carcinoma of the urinary bladder

The best answer is “Squamous-cell carcinoma of the urinary bladder”. Terminal-spined urinary eggs identify S. haematobium, whose chronic egg-driven inflammation causes squamous metaplasia and raises bladder squamous-cell-carcinoma risk. Chronic intestinal schistosomiasis can cause presinusoidal periportal fibrosis and portal hypertension while hepatocellular synthetic function remains relatively preserved.

Reference: WHO schistosomiasis fact sheet: https://www.who.int/news-room/fact-sheets/detail/schistosomiasis