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Mucormycosis Histopathology — SCE Infectious Diseases MCQ

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HardFungal InfectionsMucormycosis HistopathologySCE Infectious Diseases

A patient in diabetic ketoacidosis develops rapidly progressive sinusitis, proptosis and ophthalmoplegia. Tissue shows broad pauci-septate ribbon-like hyphae with irregular wide-angle branching. What is the diagnosis?

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Correct answer: C — Rhino-orbital-cerebral mucormycosis with broad pauci-septate hyphae

The best answer is “Rhino-orbital-cerebral mucormycosis with broad pauci-septate hyphae”. The host factor, angioinvasive syndrome and broad pauci-septate hyphae identify mucormycosis, which requires urgent liposomal amphotericin B, reversal of ketoacidosis and surgical debridement where possible. Mucormycosis diagnosis requires urgent tissue assessment; management combines reversal of predisposing factors, a liposomal amphotericin formulation plus surgical debridement where feasible.

Reference: Global guideline for the diagnosis and management of mucormycosis: https://pmc.ncbi.nlm.nih.gov/articles/PMC8559573/