Sepsis Six — SCE Infectious Diseases MCQ
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Correct answer: D — Document indication and review time, then narrow, switch or stop treatment
The best answer is “Document indication and review time, then narrow, switch or stop treatment”. Urgency and stewardship are compatible: the initial regimen is proportionate to risk, while explicit review using microbiology, source control and clinical trajectory prevents unnecessary broad exposure. Sepsis care combines urgent risk-stratified antimicrobials with cultures where this does not delay treatment and documented review, narrowing or stopping when evidence changes.
Reference: NICE NG253: suspected sepsis in people aged 16 or over: https://www.nice.org.uk/guidance/ng253/chapter/Recommendations