Shingrix in HIV — SCE Infectious Diseases MCQ
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Correct answer: E — Use the recombinant zoster vaccine according to the immunocompromised schedule
The best answer is “Use the recombinant zoster vaccine according to the immunocompromised schedule”. The recombinant vaccine is non-live and specifically recommended for eligible immunocompromised adults; previous zoster does not reliably prevent recurrence. “Use BCG as a non-specific immune stimulant” is less appropriate because it conflicts with the decisive clinical feature or cited guidance. “Use childhood varicella vaccine as treatment for established recurrent zoster” is less appropriate because it conflicts with the decisive clinical feature or cited guidance. “Use live zoster vaccine irrespective of immune status” is less appropriate because it conflicts with the decisive clinical feature or cited guidance. “Withhold vaccination because prior shingles guarantees lifelong protection” is less appropriate because it conflicts with the decisive clinical feature or cited guidance.
Reference: UKHSA Green Book chapter 28a: shingles: https://www.gov.uk/government/publications/shingles-herpes-zoster-the-green-book-chapter-28a