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Lung Abscess — SCE Infectious Diseases MCQ

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HardRespiratory InfectionLung AbscessSCE Infectious Diseases

A patient with proven invasive aspergillosis has congenital familial short-QT syndrome and requires an alternative to voriconazole. Which statement about isavuconazole is decisive?

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Correct answer: E — It is contraindicated because it shortens QTc in a concentration-dependent manner

Explanation lettering: E = shown as A · A = shown as B · B = shown as E

B is correct. Unlike most triazoles, isavuconazole shortens rather than prolongs QTc, and the UK SmPC contraindicates it in familial short-QT syndrome. The property is concentration dependent and also warrants caution with other QT-shortening medicines. Telemetry does not neutralise a formal contraindication, absence of QT prolongation does not mean electrophysiological neutrality, and the restriction is not based on a long-QT threshold. A different active antifungal strategy requires specialist selection.

Reference: Cresemba SmPC: https://www.medicines.org.uk/emc/product/5069/smpc