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Early MF Diagnosis — SCE Dermatology MCQ

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HardSkin CancerEarly MF DiagnosisSCE Dermatology

A patient has slowly progressive asymmetrical patches in a bathing-trunk distribution. An initial biopsy shows non-specific dermatitis, but lesions become increasingly infiltrated. What is the most appropriate next diagnostic step?

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Correct answer: E — Repeat biopsies from untreated representative lesions

Early mycosis fungoides may be histologically non-specific. Repeated adequately sized biopsies from representative untreated lesions, interpreted with clinical findings, immunophenotyping and selective clonality studies, are often necessary before the diagnosis can be established.

Reference: https://academic.oup.com/bjd/article/180/3/496/6749857