Grover Disease — SCE Dermatology MCQ

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EasyInflammatory DermatosesGrover DiseaseSCE Dermatology

A 65-year-old man has Grover disease (transient acantholytic dermatosis). He develops crops of intensely pruritic keratotic papules on his trunk during a febrile illness. Biopsy shows focal acantholysis. What is the typical clinical course?

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Correct answer: E — Usually self-limiting over weeks to months; may recur with heat, sweating, or systemic illness

Grover disease is usually self-limiting, resolving over weeks to months. It is exacerbated by heat, sweating, bed rest, and febrile illness — hence its predilection for middle-aged and elderly men during winter (heated environments) or systemic illness. The histology shows focal acantholysis in several patterns (Darier-like, Hailey-Hailey-like, pemphigus-like, spongiotic). Treatment is symptomatic: medium-potency topical corticosteroids, antipruritic agents, and reducing triggers (cooling measures, moisture-wicking clothing). Persistent cases may benefit from oral retinoids. Despite being called 'transient,' some cases persist for months to years with a relapsing course.

Reference: BAD 2019; Dermatopathology