SCLE — SCE Dermatology MCQ

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HardConnective Tissue & VasculitisSCLESCE Dermatology

A 40-year-old woman has subacute cutaneous lupus erythematosus (SCLE). She has annular polycyclic plaques on sun-exposed areas. What autoantibody is most strongly associated?

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Correct answer: B — Anti-Ro (SSA)

The best answer is “Anti-Ro (SSA)”. Cutaneous lupus phenotypes are distinguished by morphology, distribution, photosensitivity, histology and systemic context; serology supports but does not replace clinicopathological assessment. The alternatives “Anti-Sm”, “Anti-dsDNA”, “Anti-Jo-1”, “Anti-centromere” are clinically adjacent possibilities, but they do not fit the defining morphology, distribution, histopathology, risk signal or management sequence in this stem.

Reference: DermNet specialist cutaneous lupus reference: https://dermnetnz.org/topics/cutaneous-lupus-erythematosus