Fusidic Acid Duration — SCE Dermatology MCQ

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EasyCutaneous InfectionFusidic Acid DurationSCE Dermatology

A 40-year-old woman with eczema has secondary infection. Her GP prescribes topical Fusidic acid. According to BAD guidelines, what is the maximum recommended duration for topical Fusidic acid?

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Correct answer: D — 2 weeks maximum — to prevent resistance development

BAD and NICE guidelines recommend that topical Fusidic acid should be used for a maximum of 2 weeks to minimise the development of Fusidic acid-resistant Staphylococcus aureus. Resistance rates to Fusidic acid have increased significantly (approaching 30% in some UK settings) partly due to overprescription and prolonged courses. For infected eczema, a 2-week course of topical Fusidic acid (often combined with a topical corticosteroid — e.g., Fucibet/Fucicort) is appropriate. If infection persists beyond 2 weeks, reassess — consider alternative topical antiseptics (Chlorhexidine, Octenisan), oral antibiotics with culture guidance (Flucloxacillin if MSSA), or other diagnoses (contact allergy to the Fusidic acid itself).

Reference: BAD 2020 AD; NICE CKS; PHE Antimicrobial Stewardship