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Pemphigus Vulgaris Histology — SCE Dermatology MCQ

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HardBlistering DiseasesPemphigus Vulgaris HistologySCE Dermatology

A patient with Castleman disease has severe refractory stomatitis, polymorphous skin lesions and bronchiolitis obliterans. Which serological finding most strongly supports paraneoplastic pemphigus?

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Correct answer: D — Antibodies to envoplakin and periplakin

Autoantibodies to plakin-family proteins, particularly envoplakin and periplakin, strongly support paraneoplastic pemphigus in the appropriate clinical setting. The syndrome frequently affects multiple epithelia and can cause treatment-resistant bronchiolitis obliterans.

Reference: https://academic.oup.com/bjd/article/177/5/1170/6749752