Darier Disease Triggers — SCE Dermatology MCQ
Instant feedback + full explanation. One question, done properly.
Educational content. Not a substitute for clinical judgement or local policy.
Reveal the answer and explanation
Correct answer: A — ATP2A2 dysfunction impairing SERCA2-mediated intracellular calcium handling
Explanation lettering: D = shown as A · C = shown as B · A = shown as C · B = shown as D
D is correct. Darier disease is an autosomal-dominant ATP2A2 disorder affecting the SERCA2 calcium pump. Disrupted keratinocyte calcium signalling impairs desmosomal adhesion and differentiation, producing acantholysis and dyskeratosis; heat, sweating, friction and UV commonly aggravate it. ATP7B causes Wilson disease, ABCC6 causes pseudoxanthoma elasticum, FERMT1 causes Kindler epidermolysis bullosa and TGM1 is associated with autosomal-recessive congenital ichthyosis. The distribution and trigger pattern therefore fit a calcium-pump acantholytic disorder rather than a junctional or cornification defect.
Reference: BAD Darier disease information: https://www.bad.org.uk/pils/darier-disease