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Vitiligo Phototherapy — SCE Dermatology MCQ

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HardPhotobiologyVitiligo PhototherapySCE Dermatology

A depigmented facial patch has failed to repigment despite an adequate course of narrowband UVB. Which clinical feature most strongly suggests depletion of the follicular melanocyte reservoir and a poor phototherapy response?

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Correct answer: A — Leucotrichia within the patch

Repigmentation commonly arises from melanocytes in the hair-follicle outer root sheath. Leucotrichia indicates involvement or depletion of that reservoir and predicts a poorer response to topical treatment and phototherapy.

Reference: https://academic.oup.com/bjd/article/186/1/18/6593593