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Interface Dermatitis — SCE Dermatology MCQ

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HardInflammatory DermatosesInterface DermatitisSCE Dermatology

A patient develops a widespread eruption after allogeneic stem-cell transplantation. Biopsy shows sparse interface inflammation, basal vacuolar change, dyskeratotic keratinocytes and satellite-cell necrosis. What is the leading diagnosis?

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Correct answer: A — Acute graft-versus-host disease

Acute graft-versus-host disease can show a deceptively sparse interface dermatitis with dyskeratotic keratinocytes and lymphocyte satellitosis. Histology overlaps with drug eruption, so transplant timing, gastrointestinal or hepatic involvement and multidisciplinary correlation remain essential.

Reference: https://academic.oup.com/bjd/pages/bad-guidelines