Atopic Eczema — SCE Dermatology MCQ

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ModerateDermatopharmacologyAtopic EczemaSCE Dermatology

A 35-year-old woman with moderate eczema is prescribed Crisaborole ointment. What is the mechanism of action?

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Correct answer: B — Phosphodiesterase-4 inhibition

Crisaborole is a topical phosphodiesterase-4 inhibitor. PDE4 inhibition increases intracellular cyclic AMP and reduces pro-inflammatory cytokine signalling. This mechanism differs from topical calcineurin inhibitors, JAK inhibitors and systemic biologics used in atopic dermatitis.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/skin-conditions