Calcinosis Cutis — SCE Dermatology MCQ

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HardConnective Tissue & VasculitisCalcinosis CutisSCE Dermatology

A child with juvenile dermatomyositis develops marked limb oedema, severe weakness and extensive calcinosis. Which myositis-specific antibody is most strongly associated with this phenotype?

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Correct answer: D — Anti-NXP2

Anti-NXP2 is associated with severe muscle disease, oedema and an increased risk of calcinosis, particularly in juvenile dermatomyositis. Anti-MDA5 is linked to ulcerative amyopathic disease and rapidly progressive interstitial lung disease; anti-TIF1-gamma is associated with malignancy in adults.

Reference: https://academic.oup.com/bjd/pages/bad-guidelines